Expression of Oncofetal Protein IMP3 in Lymph Node Metastases of Small Intestine Neuroendocrine Neoplasms: A New Predictor of Recurrence

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Introduction: Small intestine neuroendocrine neoplasm (SINENs) are heterogeneous neoplasms arising from endocrine cells of the intestinal mucosa. Ki67 is the main determinant of prognosis in NENs. However, the research for new prognostic makers represent a key-point. The oncofetal protein IMP3 plays a role in cell growth and its expression has a prognostic value in lung neoplasms.

Aim(s): To text IMP3 expression in SINENs.

Materials and methods: From January 1998 to August 2015, 51 consecutive SINENs patients (34M, median age 68 yrs), suitable for surgery were studied. In all cases IMP3 expression was evaluated on primary tumors and, when available, on nodal and distant metastases.The medical records and pathological slides were used to determine clinical characteristics, pathological diagnoses, and outcome information.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Cavalcoli F

Authors: Massironi S, Del Gobbo A, Cavalcoli F, Fiori S, Conte D,

Keywords: IMP3, intestinal NENs,