Incidence and prevalence of gastric neuroendocrine tumors in patients with chronic atrophic autoimmune gastritis

#3861

Introduction: The incidence of type I gastric neuroendocrine neoplasms (gNEN) has increased substantially over the past 50 years, although studies evaluating the association with chronic autoimmune atrophic gastritis (CAAG) in the long term have been inconsistent.

Aim(s): The main aim was to evaluate the incidence of type I gNENs in a cohort of CAAG patients with a long follow-up.

Materials and methods: From October 2020 to May 2022, patients with a histologic diagnosis of CAAG were enrolled; circulating levels of chromogranin A (CgA) and gastrin were assessed at enrolment. Included patients underwent regular endoscopic follow-up, to assess for gastric neoplastic lesions, enterochromaffin-like (ECL) cell hyperplasia, and the development of gNEN.

Conference:

Presenting Author: Gallo C

Authors: Gallo C, Laffusa A, Elvevi A, Mass S,

Keywords: atrophic gastritis, autoimmune gastritis, gastrin, neuroendocrine tumor,