Incomplete Peptide Receptor Radionuclide Therapy Courses - Are We Selecting Our Patients Appropriately?

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Introduction: As per recommendations, a Peptide Receptor Radionuclide Therapy (PRRT) with Lu-177 DOTATATE course usually consists of 4 cycles. Patients may discontinue a PRRT course early, either due to progression or toxicity. Limited data are available about predictive factors for PRRT early discontinuation.

Aim(s): To assess reasons and predictive factors associated with incomplete PRRT courses in advanced Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEPNEN).

Materials and methods: Eighty six out of 487 patients (17.6%) with GEPNEN who failed to complete 4 cycles of PRRT were included and divided into two groups. Group A included pts with severe toxicity and Group B those with symptomatic or radiological progression, or death. Fisher’s exact test, logistic regression and multivariate analysis were performed.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Julian G

Authors: Gertner J, Groves J, Aziz B, Miah L, Furtado O'Mahony L,

Keywords: prrt,