Interest of serum and urinary 5HIAA, serotonin, chromogranin A and NT-proBNP assays as predictive factors for the development of carcinoid heart disease in neuroendocrine tumors

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Introduction: Carcinoid heart disease (CHD) is the main complication of carcinoid syndrome (CS) in patients with neuroendocrine tumors (NETs) and has a poor prognosis, with treatment based mainly on high-risk valve replacement surgery.

Aim(s): We developed this study to investigate the value of different biomarkers for early detection of CHD.

Materials and methods: We included patients followed at the RENATEN/ENETS center in Lyon with advanced or metastatic ileal, pulmonary, or other primary NETs with clinical CS or elevated urinary 5HIAA (u5HIAA), with available serum samples stored for the determination of various biomarkers. The main objective was to study the ability of the following biomarkers to predict the development of CHD: serum 5HIAA (s5HIAA), u5HIAA, serotonin, chromogranin A (CgA), NT-proBNP.

Conference:

Presenting Author: Walter T

Authors: Lecoeur A, Sfeir R, Damour J, Lombard-Bohas C, Gerard L,

Keywords: neuroendocrine tumors, carcinoid syndrome, carcinoid heart disease, serum 5HIAA, urinary 5HIAA, serotonin, chromogranin A, NT-proBNP,