Localisation of Insulinoma and Beta-Cells: Comparison of Glucagon-Like Peptide-1 Receptor (GLP1-R) SPECT/CT, PET/CT and MRI. Preliminary Results of a Prospective Clinical Study.

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Introduction: SPECT/CT imaging with GLP1-R specific radiotracers like 111In-DOTA-exendin-4 have already proved to be a useful tool for the preoperative localisation of insulinomas. PET/CT has several advantages over SPECT/CT: lower radiation exposure, less time consumption and higher spatial resolution.

Aim(s): We aimed at prospectively comparing the detection rate of GLP1-R PET/CT vs GLP1-R SPECT/CT vs standardized contrast enhanced 3T MRI in patients with hyperinsulinemic hypoglycemia.

Materials and methods: Eleven adult Patients with neuroglycopenic symptoms due to endogenous hyperinsulinemic hypoglycemia were enrolled. Contrast media enhanced 3T MRI was performed. SPECT/CT imaging was performed with 111In-DOTA-exendin-4 and PET/CT with 68Ga-DOTA-exendin-4. Gold standard was the histological diagnosis.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Rottenburger C, Antwi K, Heye T, Fani M, Nicolas G,

Keywords: Insulinoma, Nesidioblastosis, Glucagon-like Peptide-1 Receptor, PET/CT, SPECT/CT,