Metabolomic profile of extra-pancreatic NET: A novel prognostic tool?

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Introduction: Reprogrammed metabolism is one of the key hallmarks of cancer. Thus, metabolic profiling of cancer patients represents a promising tool. To date, metabolomics remains largely unexplored in NETs.

Aim(s): To comprehensively characterize the metabolomic profile of NETs to functionally typify molecular pathways relevant for patients’ survival.

Materials and methods: Multiplatform untargeted metabolomic profiling was performed in plasma of 77 G1-2 extra-pancreatic NETs enrolled in the phase 3 AXINET GETNE trial (ClinicalTrials.gov Identifier: NCT01744249) (study cohort) and of 68 non-cancer individuals (control cohort).

Conference:

Presenting Author:

Authors: La Salvia A, Soldevilla B, Lens-Pardo A, López-López A, Carretero C,

Keywords: NET, metabolic signaling, molecular pathways, plasma metabolites, prognostic biomarker,