Microvessel Density and Prognosis of Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETS)

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Introduction: The role of anti-angiogenic agents in GEP-NETS remains to be established. CD105 (Endoglin) identifies the TGF-ß1 receptor which is expressed on endothelial cells involved in tumor angiogenesis.

Aim(s): Preliminary study to determine the association between microvessel density (MVD), determined by CD105 expression, GEP-NET stage and prognosis.

Materials and methods: Thirty-nine patients with GEP-NETs were included in the study. A tissue microarray of tumor representative areas was made. After the immunohistochemical assay for CD105, CD31 and Ki-67, areas of the tumor with the largest number of micro-vessels (“hot spots”) were chosen and the number of microvessels per large magnification field was determined.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Soares C, Bettencourt H, Preto J, Soares P, Pinto-de-Sousa J,

Keywords: gastroenteropancreatic neuroendocrine tumors, angiogenesis, microvessel density, CD105, Endoglin,