Molecular deciphering of primary liver neuroendocrine neoplasms confirms its distinct existence with foregut-like profile

#3397

Introduction: Isolated hepatic localizations of neuroendocrine tumors (NETs) are generally considered as metastatic NETs of unknown primary but could correspond to primary hepatic NETs (PHNETs), a poorly explored entity.

Aim(s): Describe the clinicopathological and molecular features of PHNETs and compare them with other primary NETs.

Materials and methods: We included all consecutive patients managed in one expert center, for hepatic localization of NET without extra-hepatic primary tumor after exhaustive work-up (initial and follow-up). All PHNET specimens were centrally reviewed with thorough immunohistochemical characterization. We performed whole-exome sequencing with mutational and copy number analysis. Transcriptomic profile was compared to pancreatic (n=31), small-bowel (n=22) and lung (n=15) NETs using principal component analysis, unsupervised clustering and gene-set enrichment analysis.

Conference:

Presenting Author:

Authors: de Mestier L, Nicolle R, Poté N, Rebours V, Hentic O,

Keywords: liver, unknown primary, DNA sequencing, RNA sequencing, immunohistochemistry,