Molecular Signature of Rectal Neuroendocrine Neoplasia
Introduction: Rectal neuroendocrine tumors are rare neuroendocrine neoplasias (NEN). Little is known about prevalence and type of somatostatin receptor subtypes (sstr) expression and somatic mutations in relation to long-term clinical outcome.
Aim(s): To define molecular signatures that characterize distinct NEN within the intestinal tract (ileal, appendiceal and rectal NEN) and to explore whether molecular profiles mirror distinct tumor behaviour.
Materials and methods: Tumor specimens from 59 patients with NEN (12 appendiceal, 32 ileal (21 with distant metastases) and 15 rectal NEN (7 with distant metastases)) were analyzed. Expression of sstr2a and 5 was studied by immunohistochemistry and mutation screening was performed in 47 genes by next generation sequencing.
Conference: 17th Annual ENETSConcerence (2020)
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