Abstract Library

#4441 Gastric neuroendocrine neoplasms in younger patients: A retrospective single-centre study

Introduction: Gastric neuroendocrine neoplasms (gNENs) are rare neoplasms arising from stomach enterochromaffin-like (ECL) cells. Type I gNENs are the most common type, typically indolent and arising in the context of chronic atrophic gastritis (CAG). While type I gNENs are generally diagnosed in pts over 50, their occurrence in younger pts raises concern about the onset of CAG-related complications at an earlier age, potentially affecting tumour growth and clinical outcomes. Young-oriented studies on type I gNETs are still lacking in literature.

Conference:

Presenting Author:

Authors: Romano E, Rinzivillo M, Marasco M, Dell' Unto E, Esposito G,

Keywords: Gastric neuroendocrine neoplasm, Young adults, Chronic Atrophic Gastritis,

#4367 Comparative analysis of post-pancreatic surgical complications in elderly versus younger patients with inactive neuroendocrine pancreatic tumours

Introduction: The management of small, asymptomatic non-functional pancreatic neuroendocrine neoplasms (NF-pNENs) is contentious, with two main approaches: surgical resection and "watch-and-wait." Current guidelines recommend monitoring NF-pNENs under 2 cm based on retrospective data, although recent U.S. studies suggest improved survival with surgery for 1-2 cm NF-pNENs. Some suggest the "watch-and-wait" approach for older patients, though its efficacy is unclear.

Conference:

Presenting Author: Zamparas A

Authors: Zamparas A, Aghamaliyev U, Seidel G, Meyer Y, Werner J,

Keywords: nf-pnen, popf, pancreatic surgery, pNEN, pancreas,

#4317 Late diagnosis of MEN2A syndrome: Ten cases in one family

Introduction: Multiple endocrine neoplasia type 2 (MEN2) constitutes a rare hereditary cancer syndrome affecting various endocrine glands.

Conference:

Presenting Author:

Authors: Asanova A, Shutova A, Dzeranova L, Przhiyalkovskaya E, Pigarova E,

Keywords: MEN2A, RET, MTC, THYROIDECTOMY,

#4169 Germline mutation spectrum of neuroendocrine tumors

Introduction: Neuroendocrine tumors (NETs) are rare and highly heterogeneous tumors. Some specific hereditary syndromes enhance the incidence of NETs, suggesting that germline variation may contribute to neuroendocrine tumorigenesis. However, germline genetic variants in Chinese NET patients remain unclear.

Conference:

Presenting Author:

Authors: Sun Y, Tan H, Dong L, Jiang L, Zhao H,

Keywords: germline mutation, neuroendocrine tumor, genetic,

#2965 Molecular Signature of Rectal Neuroendocrine Neoplasia

Introduction: Rectal neuroendocrine tumors are rare neuroendocrine neoplasias (NEN). Little is known about prevalence and type of somatostatin receptor subtypes (sstr) expression and somatic mutations in relation to long-term clinical outcome.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Unger N, Theurer S, Herold T, Weber F, Dralle H,

Keywords: Somatic Mutations, NGS, Somatostatin receptor subtypes, Intestinal NEN,