Multivariate survival analyses of 544 advanced high-grade digestive neuroendocrine neoplasms (NET G3 and NEC) given first-line chemotherapy (NORDIC NEC 2)

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Introduction: Digestive high-grade neuroendocrine neoplasms (HG-NEN) are rare and consist of neuroendocrine tumours G3 (NET G3) and neuroendocrine carcinomas (NEC). They differ in clinical and molecular characteristics, response to treatment and prognosis. Limited prospective data are available on prognostic factors for survival in patients given first-line chemotherapy outside of clinical trials.

Aim(s): Identify prognostic factors for advanced digestive NET G3 and NEC.

Materials and methods: Patients diagnosed with a verified or suspected primary digestive HG-NEN were prospectively included 2013-2017 at nine Scandinavian hospitals. Due to altered WHO 2019 classification, a centralised pathological re-evaluation was performed. Multivariate analyses (MVA) on factors prognostic for progression-free survival (PFS) and overall survival (OS) was performed.

Conference:

Presenting Author:

Authors: Sorbye H, Hjortland G, Vestermark L, Ladekarl M, Svensson J,

Keywords: neuroendocrine neoplasm, neuroendocrine carcinoma, digestive, high-grade, neuroendocrine tumour grade 3,