Next Generation Sequencing of Pancreatic Neuroendocrine Tumors in Russian Cohort


Introduction: The appearance of next generation sequencing (NGS), - a powerful high-performance method, allowed accumulation of a large amount of information concerning genetic and epigenetic patterns, however, the problem of matching clinical, histological picture with genetic structure in pNETs remains open.

Aim(s): To conduct analysis of signaling pathways and candidate genes - potentially associated with the development of pNETs

Materials and methods: Clinical, pathological data of retrospective group of 24 patients (10 men, 14 women, median age – 59 years) with a diagnosis of pancreatic NET was analyzed. All patients were treated in Rostov Research Oncological Institute from 2011 to 2018. DNA was extracted from paraffin blocks. Genomic DNA was used for mass parallel sequencing based on the target gene panel (409 genes) of the IlluminaNextSeq550 platform

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Trifanov V

Authors: Trifanov V, Kit O, Timoshkina N, Gvaldin D, Karnauhov N,

Keywords: Next generation sequencing, pancreatic neuroendocrine tumors,

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