Nucleolin (NCL) Regulates Aerobic Glycolysis in Pancreatic Neuroendocrine Tumor (p-NET) BON-1 Cells
#1742
Introduction: NCL, a nucleolus localized protein and ribosomal RNA (rRNA) expression regulator, has been reported to function as an oncogene in several tumors. However, the expression and role of NCL in p-NET remains unclear.
Aim(s): In this study, we aimed to evaluated the expression status and function role of NCL in p-NET BON-1 cells.
Materials and methods: Using Immunohistochemistry (IHC) methods, we examined the expression status of NCL in p-NET patients. We silenced NCL expression in BON-1 cells, and examined the role of NCL in BON-1 cell proliferation. To uncover the underlying molecular mechanism, we analyzed the role of NCL rRNA expression, ATP production and aerobic glycolysis.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author:
Keywords: pancreatic neuroendocrine tumors (p-NETs), Nucleolin (NCL), ribosomal RNA, ATP, aerobic glycolysis,
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