Abstract Library

#4490 Parietal cell-selective Slc26a9 deletion in mice causes gasdermin D mediates mitochondrial damage and pyroptosis, which is the key event to induce autoimmune gastritis

Introduction: Autoimmune gastritis (AIG) is the basis of gastric malignancy, including neuroendocrine tumour (NET) and gastric cancer (GC). We reported that Slc26a9 is highly expressed in parietal cells (PCs), and its deficiency caused GC.

Conference:

Presenting Author: Liu X

Authors: Ji B, Deng Z, Ma Z, Li T, Tuo B,

Keywords: Slc26a9, autoimmune gastritis, Pyroptosis, gastric mucosal immunity remodelling,

#3744 Germline whole-exome sequencing of patients with neuroendocrine neoplasms reveals pathogenic or likely pathogenic variants in a large subset of patients

Introduction: The germline predisposition to neuroendocrine neoplasms (NEN) is not-well understood beyond genetic syndromes associated with MEN1 loss.

Conference:

Presenting Author: Sukrithan V

Authors: Sukrithan V, Boateng I, Jain P, Liyanarachchi S, Buss J,

Keywords: whole exome sequencing, germline, population, mutyh, pkd1, atp4a, pah,

#3424 Parietal cell-selective Slc26a9 deletion in mice results in gastric mucosal immune disorders, which is the key event to development of autoimmune gastritis

Introduction: Autoimmune gastritis (AIG) is the basis of gastric malignancy, including neuroendocrine tumor (NET) and gastric cancer. We reported that Slc26a9 is highly expressed in parietal cells (PCs), and its deficiency caused gastric cancer.

Conference:

Presenting Author: Liu X

Authors: Deng Z, Chen J, Ma Z, Tuo B, Li T,

Keywords: slc26a9, Autoimmune gastritis, gastric neuroendocrine cell,

#3398 Patient-derived tumoroids phenocopy original gastro-entero-pancreatic neuroendocrine neoplasms and facilitate in vitro drug screening

Introduction: GastroEnteroPancreatic Neuroendocrine Neoplasms (GEP-NENs) are rare cancers that appear clinically and biologically extremely heterogenous. While highly proliferative cases are invariably lethal, slower-proliferating NENs—representing predominant cases—have unpredictable clinical courses varying from indolent to malignant. Recent comprehensive NGS screens in patients helped to extend our understanding. However, complementary relevant preclinical models to address disease heterogeneity and to investigate patient-specific treatment alternatives are still inexistent.

Conference:

Presenting Author: April-Monn S

Authors: April-Monn S, Kirchner P, Detjen K, Gloor B, Partelli S,

Keywords: GEP-NEN, Organoid, Tumoroid, Model, Drug screening, translational, single-cell RNAseq, NGS, OMICs, biomarker,

#3187 Primary insulinoma of the liver

Introduction: Insulinoma is a moderately rare neuroendocrine tumor which is normally located in the pancreas. There are extremely rare cases of metastatic insulinoma. We present the case of the primary insulinoma of the liver which was successfully surgical treated.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Kaldarov A

Authors: Kaldarov A, Kriger A, Gorin D, Berelavichus S, Galkin G,

Keywords: insulinoma, liver, neuroendocrine tumor, hypoglycemia, hyperinsulinism,