Ovarian neuroendocrine tumor metastases can induce estrogen production in postmenopausal patients

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Introduction: Neuroendocrine tumors (NET) are malignant neoplasms that can be associated with specific hormonal syndromes.

Aim(s): We describe a novel syndrome of postmenopausal vaginal bleeding and ovarian estradiol overproduction due to ovarian NET localizations.

Materials and methods: A clinical workup was performed for 2 index patients with ovarian metastases of small bowel neuroendocrine tumors and symptoms of postmenopausal vaginal bleeding. Ovarian tissue was collected after oophorectomy, cultured ex vivo and incubated with anti-hormonal and antitumoral drugs. Electronic medical records were screened for postmenopausal patients with ovarian NET localizations and similar symptoms that presented in our center between 1991 and 2023.

Conference:

Presenting Author: Mulders M

Authors: Mulders M, Hofland J, de Herder W, van Velthuysen M, Roes E,

Keywords: ovary, neuroendocrine, tumor, estradiol, postmenopausal, bleeding,