Plasma Protein Kallikrein-14 Strongly Predicts Pronounced Chromogranin A (CgA) Response in Small Intestinal Neuroendocrine Tumor (NET) Patients after Somatostatin Analog (SSA) Treatment: The Nordic EXPLAIN Biomarker Study


Introduction: Predicting treatment response at an early stage in the treatment algorithm for NET is highly desirable.

Aim(s): To investigate 92 putative cancer-related proteins in plasma at the time of diagnosis and after 6 months of treatment in an attempt to explore new predictive biomarkers.

Materials and methods: One hundred small intestinal NET patients from 16 Nordic centers were prospectively followed. Blood samples were obtained before start of treatment, and 6 (±3) months after initiation of treatment. Plasma samples were analysed with Olink Proseek Multiplex Oncology II panel. Chromogranin A (CgA) was analysed centrally at Akademiska Lab Uppsala (NEOLISA Euro Diagnostica). Treatment response was analysed using a logistic regression model adjusted for the baseline CgA value and the baseline value of the biomarker.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Kjellman M

Authors: Kjellman M, Knigge u, Welin S, Grønbæk H, Thiis-Evensen E,

Keywords: Plasma Protein Biomarker,

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