Predictive factors of adverse events onset in GEP-NET patients treated with LRT

#3511

Introduction: Since metastatic GEP-NET are low-growing neoplasms, characterised by stability followed by progression, multiple lines of treatment have to be adopted to control distant localisations and symptoms. In this scenario, there are no precise models to assess the occurrence of adverse events during LRT (Ligand Radiotherapy).

Aim(s): The aim of this study is to investigate the occurrence of adverse events in GEP-NET during LRT and to evaluate the role of previous therapies and individual characteristics.

Materials and methods: G1-G2 metastatic GEP-NETs patients treated in our centre with LRT (177Lu-Oxodotreotide, 4 administrations, 7.4 GBq/each) from April 2019 to December 2020 were considered. Logistic regression with Firth correction and bootstrap procedure were performed to determine predictability of clinical features and previous therapies. Model performance was assessed by AUC.

Conference:

Presenting Author: Scalorbi F

Authors: Scalorbi F, Argiroffi G, Baccini M, Gherardini L, Fuoco V,

Keywords: lrt, toxicity, logistic regression, predictive model, gep-net,