Predictive value of high-risk histopathological- and molecular criteria for lymph node metastasis in appendiceal neuroendocrine tumours

#4566

Introduction: Appendiceal neuroendocrine tumours (aNET) are rare neoplasms for which consensus is needed for follow-up and additional treatment. To unravel the factors behind aNET which showed lymph node metastasis (LNM) in additional right hemicolectomy (RH), we evaluated high-risk histopathological parameters in aNETs and studied molecular parameters.

Aim(s): Primary objective was to evaluate predictive value of high-risk histopathological criteria (HHC), presence and pattern of serotonin and S100 expression in aNET and LNM. Secondary objective was to obtain insight in potential driver mutations in aNET.

Materials and methods: We analysed 19 samples of grade 1 and 2 aNET patients with additional RH. HHC were based on ENETS guidelines. Serotonin and S100 expression and their pattern were analysed in aNET and LNM. Also, next-generation sequencing was performed in three tumours.

Conference:

Presenting Author: Bremer B

Authors: Bremer B, Kyriskozoglou V, El Moumni M, Heideman D, Walenkamp-Hageman A,

Keywords: Appendix NET, High-risk histopathological criteria, Serotonin, Driver mutation, Right Hemicolectomy,