Abstract Library
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ENETS Abstract Search
Introduction: In spite of new treatments like PRRT or everolimus there is a clinical need for systemic therapies that complement SSAs (somatostatin analogs) and antidiarrheal agents in the treatment of carcinoid syndrome, a late stage problem in s-i-NET. Telotristat is a promising addition to our therapeutic arsenal.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Linder Ekberg K,
Keywords: telotristat, carcinoid syndrome, metastasized GI-NET,
Introduction: Increased levels of serotonin secretion are associated with mesenteric fibrosis (MF) in small intestinal neuroendocrine tumors (SI-NETs). However, only a proportion of patients with increased serotonin production will develop mesenteric fibrosis.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Blazevic A
Authors: Blazevic A, Iyer A, Van Velthuysen M, Hofland J, Franssen G,
Keywords: Small-intestinal neuroendocrine tumors, mesenteric fibrosis, serotonin, tryptophan metabolism, proteomics,
Introduction: Serotonin-secreting pancreatic neuroendocrine neoplasms (5-HT-secreting pNENs) are very rare. They are characterised by high urinary 5-hydroxyindole-acetic acid (5-HIAA) levels (or high serum 5-HT levels).
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Milanetto A, Fassan M, Gais Zürcher A, David A, Pasquali C,
Keywords: Pancreatic neuroendocrine neoplasm, primary pancreatic carcinoid, serotonin-secreting pancreatic tumour, serotonin-producing pancreatic tumour,
Introduction: Everolimus (EVE) (mTOR inhibitor) is an effective drug in the treatment of well-differentiated NETs of different localizations, however, prognostic factors for the correct choice of therapy are not well understood.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Markovich A, Kuznetsova A, Gorbunova V, Orel N, Emelianova G,
Keywords: neuroendocrine tumors, everolimus, uni- and multivariate analysis,
Introduction: Telotristat ethyl is a tryptophan hydroxylase inhibitor that has been shown to be effective against symptoms of carcinoid syndrome refractory to standard somatostatin analogue therapy by directly inhibiting serotonin production. While clinical trials have established short-term efficacy of the drug, we report an exploratory real-world study of 15 patients with metastatic neuroendocrine tumours on long-term Telotristat (median duration=8 months).
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Hota S, Cananea E, Martin W, Clement D, Solis B,
Keywords: Neuroendocrine tumours, carcinoid syndrome, telotristat ethyl,