Abstract Library

#4615 Dosimetry, efficacy and safety of radiolabelled somatostatin receptor antagonist in patients with metastatic pheochromocytoma or paraganglioma

Introduction: Metastatic pheochromocytomas and paragangliomas (mPPGLs) are rare neuroendocrine tumours with a heterogenous phenotype and a variable treatment response. The SSTR antagonist [177Lu]Lu177Lu-DOTA-JR11 (177Lu-JR11) offers potentially increased tumour doses than standard radioligand therapy (RLT) with [177Lu]Lu-DOTA-TOC (177Lu-TOC).

Conference:

Presenting Author: Lider S

Authors: Lider Burciulescu S, Schmidt F, McDougall L, Bernhardt P, Mushaweh A,

Keywords: Metastatic PPGL, radioligand therapy, somatostatin receptor antagonist, dosimetry,

#4531 The role of metabolism in neuroendocrine tumour cell models and patients

Introduction: It is recognised that the adipose tissue plays a major role in cancer through a metabolic coupling that supports tumour cell growth. Recent evidence suggests that altered metabolic pathways drive the development and influence the clinical outcomes of gastroenteropancreatic neuroendocrine tumours (GEP-NETs).

Conference:

Presenting Author: Calabrese C

Authors: Calabrese C, Dellavalle S, Miserocchi G, Gabellone S, Spadazzi C,

Keywords: tumour metabolism, adipocytes, RNA-sequencing, GEP-NET,

#4451 The management of well-differentiated gastroenteropancreatic neuroendocrine tumours in a tertiary centre – The contribution of radionuclide therapy

Introduction: Neuroendocrine tumours represent a heterogenous group of tumours with different locations, whose management is necessary to identify specific parameters that determine the choice of optimal treatment.

Conference:

Presenting Author: Oana Stefania S

Authors: Oana Stefania S, Corin B, Victoria V, Sofia L,

Keywords: GEP-NET, well-differentiated, PRRT, Cromogranine A, Serotonin, RECIST 1.1,

#4311 Characterisation of patients diagnosed with metastatic head and neck paraganglioma treated at an oncology referral institution in Colombia

Introduction: Head and neck paragangliomas (HNPGL) are rare tumours. Multiple risk factors associated with the risk of metastasis have been described, although much of the available information corresponds to the group of Pheochromocytoma and Paragangliomas, not necessarily extrapolatable to metastatic HNPGLs.

Conference:

Presenting Author: Fierro L

Authors: González A, Puerto J, Fierro L, Zarama A, Caicedo L,

Keywords: Paraganglioma, head and neck, metastasis, survival,

#4047 The role of adipocytes in neuroendocrine neoplasms: Molecular and metabolic adaptations

Introduction: It is recognized that the adipose tissue plays a major role in cancer. Recent evidence suggests the existence of altered metabolic pathways in neuroendocrine neoplasms (NENs), influencing tumor development and evolution, and thereby clinical outcomes.

Conference:

Presenting Author: Calabrese C

Authors: Calabrese C, Dellavalle S, Miserocchi G, Gabellone S, Spadazzi C,

Keywords: neuroendocrine neoplasm, adipocytes, metabolism, RNA-seq, 3D co-cultures,