Rectal Neuroendocrine Tumor with Chromogranin Expression Is Associated with Aggressive Clinical Behavior and Worse Prognosis

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Introduction: Although rectal neuroendocrine tumors (NETs) with L-cell phenotype and small tumor size generally had better clinical behavior, the new 2019 WHO classification classified all rectal NETs are malignant without considering L-cell phenotype and small tumor size. Therefore, identifying biomarkers of rectal NETs is important to stratify the clinical behavior of rectal NETs.

Aim(s): To identify clinical and prognostic significances of chromogranin labeling,

Materials and methods: chromogranin protein expression was assessed in 467 surgically or endoscopically resected rectal NETs and compared with clinicopathologic factors.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Kim J

Authors: Kim J, Kim J, Oh E, Yang D, Hong S,

Keywords: Rectal neuroendocrine tumor, Chromogranin, Immunohistochemistry, Prognosis,

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