Relevant prognostic factors in patients with stage IV small intestine neuroendocrine neoplasms

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Introduction: There are only few, but controversial data on the prognostic role of upfront primary tumor resection and mesenteric lymph node dissection (PTR) in patients with stage IV small intestinal neuroendocrine neoplasia (SI-NEN).

Aim(s): Therefore, the prognostic role of PTR was determined in this setting.

Materials and methods: This retrospective cohort study included patients with stage IV SI-NEN with unresectable metastases without clinical or radiological signs of acute bowel obstruction or ischemia. Patients diagnosed from 2002 to 2020 were retrieved from a prospective database. Disease specific overall survival (OS) was analysed regarding upfront PTR and a variety of clinical and pathological parameters by uni- and multivariate analysis.

Conference:

Presenting Author:

Authors: Maurer E, Heinzel-Gutenbrunner M, Rinke A, Rütz J, Figiel J,

Keywords: stage 4 small intestine neuroendocrine neoplasm, primary tumor resection, survival, peptide receptor radionuclide therapy,