Resection of primary tumor improves survival rate in rectal neuroendocrine neoplasms with liver metastasis

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Introduction: The current ENETS and NANETS guidelines support resection of primary tumors in advanced rectal neuroendocrine neoplasms. But there is no evidence that primary tumor resection is beneficial to the prognosis of rNENs patients with liver metastasis.

Aim(s): To provide theoretical evidence for resection of primary tumor for patients with rectal neuroendocrine neoplasms (r-NENs) with liver metastasis (LM).

Materials and methods: Two hundred and seventy-three patients with liver metastatic r-NENs who were diagnosed between 2010 and 2017 in the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively analysed. All patients were divided into primary tumor resection (PTR) and non-primary tumor resection (non-PTR) groups. The difference of survival rates was analysed by Kaplan-Meier survival curve. Univariate and multivariate Cox proportional hazard regression models were performed to determine the factors affecting survival.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Long Q, Xue J, Bai J, Hu P, Liu M,

Keywords: liver metastasis, overall survival, primary tumor resection, rectal neuroendocrine neoplasm,