RNA m6A methylation regulators in lung neuroendocrine neoplasms

#3847

Introduction: Lung carcinoids are commonly slow-proliferating neuroendocrine neoplasms (LungNENs) with a low mutational burden. Recent research has suggested a severe alteration in the profile of alternative splicing in LungNENs. In contrast, the role of emerging related systems like the genes regulating N6 methyladenosine (m6A), the most abundant internal modification of RNA, has been poorly explored in these rare tumors. We hypothesize that the expression profile of m6A-related genes could be altered in LungNENs in relation to their development.

Aim(s): Our objective was to identify alterations in the m6A process that may interfere with LungNENs development.

Materials and methods: We have performed a pilot analysis on 16 atypical carcinoids, and, through biocomputational analyses, we have assessed the expression of 13 m6A regulators, exploring their associations with clinical features.

Conference:

Presenting Author:

Authors: Ibáñez-Costa A, García Vioque V, Blázquez-Encinas R, Moreno Montilla M, Pedraza-Arévalo S,

Keywords: carcinoid, neuroendocrine tumor, lung, m6a, RNA, methylation,