Abstract Library

#4559 Exploring the interplay between RNA methylation and splicing dysregulation in neuroendocrine tumours

Introduction: Post-transcriptional modifications play crucial roles in regulating gene expression and cellular function. While recent findings indicate that alternative splicing dysregulation plays a key role in tumorigenic properties of neuroendocrine tumours (NETs), the role of other RNA processing mechanisms, such as N6-methyladenosine (m6A) — being the most common RNA methylation — remains largely unexplored in NETs.

Conference:

Presenting Author:

Authors: Ruiz-Palacios D, Gutiérrez Camacho L, García Vioque V, Moreno Montilla M, Blázquez-Encinas R,

Keywords: RNA methylation, splicing, neuroendocrine tumour, lung NET, pan NET,

#3987 m6A modifications promote the invasion and metastasis of pancreatic neuroendocrine neoplasms by activating the Integrin/FAK signalling pathway via TGFBI

Introduction: Nearly 50% of patients with pNENs have metastases at the time of initial diagnosis, and there is a lack of effective treatment once they have metastases. The 5-year overall survival rate for G3 pNENs with metastasis at diagnosis was 0, which was significantly lower than that for patients without metastasis, with a 5-year overall survival rate of 43%. At present, the pathogenesis of pNENs has not been clarified.

Conference:

Presenting Author:

Authors: Ye M, Tang Q,

Keywords: RNA methyltransferases, Tumor metastasis, Pancreatic neuroendocrine neoplasm, Transforming growth factor-β-induced gene, Integrin/FAK signaling pathway,

#3847 RNA m6A methylation regulators in lung neuroendocrine neoplasms

Introduction: Lung carcinoids are commonly slow-proliferating neuroendocrine neoplasms (LungNENs) with a low mutational burden. Recent research has suggested a severe alteration in the profile of alternative splicing in LungNENs. In contrast, the role of emerging related systems like the genes regulating N6 methyladenosine (m6A), the most abundant internal modification of RNA, has been poorly explored in these rare tumors. We hypothesize that the expression profile of m6A-related genes could be altered in LungNENs in relation to their development.

Conference:

Presenting Author:

Authors: Ibáñez-Costa A, García Vioque V, Blázquez-Encinas R, Moreno Montilla M, Pedraza-Arévalo S,

Keywords: carcinoid, neuroendocrine tumor, lung, m6a, RNA, methylation,

#3622 Hypoxia down-regulates m6A methyltransferase METTL3 and WTAP promotes pancreatic neuroendocrine tumor metastasis via regulating TGFBI

Introduction: Hypoxia is a marker of cancer progression. When faced with hypoxia, tumor cells exhibit the dynamic change of N6-methyladenine (m6A). m6A is a reversible RNA modification that plays an important role in gene expression regulation and is closely related to the occurrence and development of various tumors.

Conference:

Presenting Author: Ye M

Authors: Ye M, Bai J, Tian Y, Chen J, Lu F,

Keywords: Pancreatic neuroendocrine tumor, RNA methyltransferase, exosomes, tumor-associated macrophages, tumor metastasis,