Routine early 68Ga-DOTATATE PET/CT has low diagnostic yield after resection of pancreatic neuroendocrine neoplasms

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Introduction: Following resection of primary pancreatic neuroendocrine neoplasm (P-NEN), the reported median disease free survival is ≥4y. 68Ga-DOTATATE PET/CT (DOTA-PET) is widely used for restaging following surgical resection of P-NEN due to a higher sensitivity compared to cross-sectional imaging. We hypothesized that early DOTA-PET has a low yield in detecting recurrent/residual or distant disease in patients following curative-intent surgical resection of non-metastatic localised P-NEN.

Aim(s): To analyse the diagnostic yield of DOTA-PET following curative-intent surgical resection of non-metastatic localised P-NEN.

Materials and methods: Retrospective study (dual read) of patients restaged with DOTA-PET between 05/2011 and 03/2022; 0-16 months after curative-intent resection of P-NEN. Pre-operative DOTA-PET and initial post-operative DOTA-PET were reviewed by an experienced nuclear medicine physician.

Conference:

Presenting Author:

Authors: Singh A, Chan D, Samra J, Pavlakis N, Engel A,

Keywords: Pancreatic NEN, post-resection, restaging, early 68Ga-DOTATATE PET/CT, diagnostic yield,