Sex differences in survival of neuroendocrine neoplasms (NENs): Comparative study of patients from National Cancer Registration and Analysis Service (NCRAS, UK) and Surveillance, Epidemiology, and End Results (SEER, US) databases

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Introduction: It has been reported that sex is an important predictor of survival of NEN patients using data from the UK NCRAS database. The same statistical methods have not been applied to US SEER data.

Aim(s): To compare sex differences in survival of patients with NENs from NCRAS and SEER databases using the same statistical methods.

Materials and methods: 14,834 and 114,487 NEN patients were extracted from NCRAS (2012 - 2018) and SEER (1975 – 2020) respectively. Included sites were appendix, cecum, colon, lung, pancreas, rectum, small intestine, and stomach. 60-month Restricted mean survival time (RMST), age-adjusted restricted mean time lost ratio (RMTL ratio), age-adjusted hazard ratio and Kaplan Meier curves were generated for males and females for all sites and for some subgroups (age, grade, and stage).

Conference:

Presenting Author:

Authors: Mortagy M, El Asmar M, Chandrakumaran K, Ramage J,

Keywords: SEER, NCRAS, Neuroendocrine tumor, RMST, Cox regression, Survival analysis, Sex differences, RMTL, Kaplan Meier,