Sexual dimorphism in small intestinal NETs: Any association with development of mesenteric metastases?

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Introduction: Small-intestinal neuroendocrine tumors (SI-NET) are rising in incidence and complications such as mesenteric and hepatic metastases are associated with increased morbidity and mortality. It has recently been suggested that mesenteric metastases risk increases in women around menopause.

Aim(s): The aim of this study was to analyse sexual dimorphism in a large cohort of patients with SI-NET.

Materials and methods: Data collected from patient records for 849 patients (recruited 2009-2021) was analysed for the presence of sexual dimorphism in key characteristics such as age, sex, grade, stage, presence of mesenteric metastases and size, presence of fibrosis and urinary 5HIAA. Survival analysis was conducted for male and female patients, mesenteric metastases, mesenteric fibrosis and tumor multifocality.

Conference:

Presenting Author: Castanho Martins M

Authors: Hassan D, Bally D, Castanho Martins M, Hodgetts H, Rombouts K,

Keywords: small intestine, mesenteric metastases, mesenteric fibrosis, sexual dimorphism, sex hormone,