SOMscan: Towards a Ga-68-labeled Pan-Somatostatin PET Imaging Probe Based on SOM230 (Pasireotide)

#447

Introduction: The somatostatin receptor subtype sst2 is largely expressed on neuroendocrine tumors. However, current clinical studies indicate that the subtypes sst1, 3, 5 are of substantial relevance as well.

Aim(s): We intend to develop a Ga-68-PET tracer covering a broad spectrum of ssts for clinical application.

Materials and methods: The sst1, 2, 3, 5 highly specific SOM230 (Pasireotide) was coupled with the chelators DOTA or NODAGA and labeled with Ga-68. We investigated the tracers’ sst-subtype binding and internalization profiles in vitro and the biodistribution and tumor uptake by microPET studies in hsst2- and hsst5-tumor xenografts.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Fani M, Braun F, Mann A, Kiewer A, Kaufmann J,

Keywords: SOM230, Ga-68, PET imaging,

To read the full abstract, please log into your ENETS Member account.