Telomerase-independence function of Dyskerin is therapeutic vulnerability in TP53 mutant pancreatic neuroendocrine tumors

#3925

Introduction: Pancreatic neuroendocrine tumors (PanNETs) utilize the recombination-mediated alternative lengthening of telomeres (ALT) mechanism, rather than telomerase, for the maintenance of telomeres.

Aim(s): To make clear the association between telomerase component and clinical practice, particularly chemotherapy resistance.

Materials and methods: We used single cell and omics techniques to explore the relationship between telomerase components and TMZ resistance. And verified our findings in the PDC PDO PDX model from a TP53 mutant patient.

Conference:

Presenting Author: Ji S

Authors: Ji S, Lou X, Zhou C, Xu X, Chen J,

Keywords: pancreatic neuroendocrine tumor, tp53 mutant, dyskerin, temozolomide,