The Predictive Value of Gastrin Levels for the Diagnosis of Gastric Enterochromaffin-like Cells Hyperplasia, in Patients with Hashimoto’s Thyroiditis

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Introduction: Gastrin and chromogranin A (CgA) levels have been tested for the diagnosis of enterochromaffin-like cell hyperplasia (ECLH), in patients with type 1 diabetes and autoimmune atrophic gastritis but there are no data for patients with Hashimoto's thyroiditis (HT).

Aim(s): To develop receiver operating characteristic (ROC) curves for gastrin and CgA levels and other clinical and biochemical parameters as a means for pretest probability of gastric ECLH in patients with HT.

Materials and methods: One-hundred and fifteen patients with HT were prospectively studied for a median period of four years (2-7 years). Gastrin, CgA, vitamin B12, anti-parietal cell antibodies, free-thyroxine, thyrotropin, and neuron-specific enolase level measurements.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Nikolaou A, Thomas D, Alexandraki K, Sougioultzis S, Tsolakis A,

Keywords: enterochromaffin-like cell hyperplasia, gastrin, thyroiditis,