The Proinflammatory Molecule, VAP-1, Is Enriched in the Stroma of Midgut NETs and Plaques of Carcinoid Heart Disease Valves


Introduction: Vascular adhesion protein-1 (VAP-1) is a novel driver of tissue inflammation and fibrosis.

Aim(s): We studied the tissue expression of VAP-1 in midgut NETs and carcinoid heart disease (CHD). Circulating soluble VAP-1 (sVAP-1) was measured to evaluate its potential use as a biomarker of fibrosis in NETs.

Materials and methods: Expression of VAP-1 and extracellular matrix (ECM) markers in paraffin-embedded midgut NETs tissue, CHD valves and control valves was assessed using immunohistochemistry. sVAP-1 concentration was measured by ELISA in serum collected from two independent NET centres.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Shah T, Sagar V, Neil D, Liu B, Barriuso J,

Keywords: carcinoid, GEP-NET, VAP-1, ECM, tumour stroma, biomarker,

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