The role of the gut microbiome in patients with midgut neuroendocrine tumors

#3774

Introduction: When compared to other cancers, the prevalence of midgut neuroendocrine tumors (NETs) has disproportionally increased over the past decades. To date, very little progress has been made in the discovery of (epi)genetic drivers and treatment options of these tumors. Recent microbiome research has provided novel treatment targets among various cancer types. However, its role in midgut NETs and the Carcinoid Syndrome (CS), a frequently present syndrome of hormonal hypersecretion, has not been studied.

Aim(s): To analyse the role of the gut microbiome of midgut NET patients.

Materials and methods: Fecal samples, collected from patients and controls, were analysed with next generation 16S sequencing. Relevant variables were extracted from questionnaires and electronic health records. Microbial composition was compared between patients and controls as well as between patients with and without CS.

Conference:

Presenting Author:

Authors: Mulders M, Audhoe A, Kraaij R, van Koetsveld P, Feelders R,

Keywords: gut, microbiome, neuroendocrine, tumor, carcinoid, syndrome, diagnosis,