#4166
Characterising the tumor microenvironment of multifocal small intestinal NETs
Introduction:
Small intestinal neuroendocrine tumors (SI-NETs) are thought to arise from enterochromaffin cells of the gut, often with multiple synchronous primary tumors. Recently, we showed that synchronous primary tumors from the same SI-NET patient display distinct somatic mutational profiles, suggesting that these tumors originate independently, despite few clear driver mutations. Thus, new mechanistic insights into multifocal SI-NETs are urgently needed.
Conference:
Presenting Author:
Authors:
Mäkinen N,
Lee I,
Dohlman A,
Gao T,
Zhang Z,
Keywords:
small intestinal NET,
tumor microenvironment,
tumor microbiome,
#3774
The role of the gut microbiome in patients with midgut neuroendocrine tumors
Introduction:
When compared to other cancers, the prevalence of midgut neuroendocrine tumors (NETs) has disproportionally increased over the past decades. To date, very little progress has been made in the discovery of (epi)genetic drivers and treatment options of these tumors. Recent microbiome research has provided novel treatment targets among various cancer types. However, its role in midgut NETs and the Carcinoid Syndrome (CS), a frequently present syndrome of hormonal hypersecretion, has not been studied.
Conference:
Presenting Author:
Authors:
Mulders M,
Audhoe A,
Kraaij R,
van Koetsveld P,
Feelders R,
Keywords:
gut,
microbiome,
neuroendocrine,
tumor,
carcinoid,
syndrome,
diagnosis,
