The usefulness of circulating fibrosis markers in detection of carcinoid heart disease

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Introduction: Carcinoid heart disease (CHD) is a potential serious fibrotic complication in patients with neuroendocrine neoplasms (NENs), affecting the heart valves. Early detection is crucial to avoid severe manifestations. NT-proBNP is suggested as an initial screening tool in detection of CHD; however, the value of NT-proBNP as a screening tool is questionable.

Aim(s): We aimed to investigate the usefulness of circulating fibrosis markers as a screening tool in detection of CHD.

Materials and methods: We included patients with disseminated small intestinal NEN. We performed transthoracic echocardiography (TTE) for the diagnosis of CHD, and blood samples were drawn for measurement of different circulating fibrosis markers (CALC2, MIM, PRO-C3, PRO-C6, TIM, C2M, C3M, C6Ma3). The area under the receiver operating characteristic (AUROC) curve was calculated to evaluate the usefulness of fibrosis markers as a screening tool for detection of CHD.

Conference:

Presenting Author: Lau T

Authors: Lau T, Angeli E, Oksjoki R, Rasmussen V, Genovese F,

Keywords: carcinoid heart disease, biomarker, fibrosis marker,