Thinking and confusion about a well-differentiated grade 3 pancreatic neuroendocrine tumor

#3120

Introduction: In WHO Classification of Digestive System Tumors (2019 edition), pancreatic NENs are divided into well-differentiated NETs (including G1, G2, G3) and poorly differentiated NECs mainly based on the mitoses and Ki-67. G3 pNET and pNEC should have more than 20 mitoses/10 HPFs or their Ki-67 should be higher than 20%. However, WHO didn't clearly distinguish the Ki-67 cut-off value between them, and only 55% was recommended.

Aim(s): To explore the pathology and molecular genetics of a G3 pNET.

Materials and methods: A 48-yr-old male was diagnosed as G3 pNET. The pathology and whole exon sequencing of primary neoplasm and 3 metastases were performed.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Ma Y

Authors: Ma Y, Song L, Li X, Yang M, Wang F,

Keywords: pancreatic neuroendocrine carcinoma, pancreatic neuroendocrine tumor, G3, P53, ATRX, DAXX, MEN1,