To determine the true incidence of brain metastases in atypical lung neuroendocrine tumors and explore factors that increase the risk of intracranial disease

#3156

Introduction: Lung neuroendocrine tumors (NETs) make up 25% of all NETs. Typical carcinoid (TC) and atypical carcinoid (AC) account for 2% and 0.2% of all lung NETs respectively, and AC tend to be more aggressive. Although both can metastasise, AC are more likely; common sites include bone and liver. Currently, brain imaging is not included in the work-up of TC/AC, as <5% of cases are thought to develop brain metastases (BM). However, evidence suggests this may be an underestimate. Identifying BM would inform management and could improve prognosis. Thus, evaluating the incidence in TC/AC is needed to ascertain whether there is justification for baseline brain imaging. Furthermore, Ki-67 could be useful as a predictive tool.

Aim(s): To review the incidence of BM in TC/AC to determine whether there is justification for routine brain imaging and to explore factors which could increase the risk of BM.

Materials and methods: Single site, retrospective analysis of 287 patients with TC/AC over a 13-year period. Incidence of BM (as detected on CT/MRI), at diagnosis or during the course of the disease, was reviewed.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Jones J, Spurgeon L, Shaheen F, Lewis A, Mansoor W,

Keywords: typical carcinoid, atypical carcinoid, brain metastases, Ki67,