Abstract Library

#4209 Transcriptomic and spliceosomic landscapes of pancreatic neuroendocrine tumors generated through Oxford Nanopore Technology sequencing

Introduction: Pancreatic Neuroendocrine tumors (PanNETs) are rare neoplasms with heterogenous nature, still poorly understood. Their low mutational burden has prompted to explore other molecular aspects, from epigenomics to transcriptomics. Increasing evidence indicates that transcriptomic changes, often derived from alterations in alternative splicing, can generate isoforms with oncogenic potential. In this context, long-read Oxford Nanopore Technology (ONT) has emerged as an ideal suited sequencing tool to deeply study transcriptomics and splicing variants.

Conference:

Presenting Author: Moreno Montilla M

Authors: Moreno Montilla M, Jones G, Jeffries A, Blazquez Encinas Rey R, Bamford R,

Keywords: Pancreatic Neuroendocrine Tumor, Oxford Nanopore Technology Sequencing, Transcriptomics, Splicing, Fusion Genes,

#3156 To determine the true incidence of brain metastases in atypical lung neuroendocrine tumors and explore factors that increase the risk of intracranial disease

Introduction: Lung neuroendocrine tumors (NETs) make up 25% of all NETs. Typical carcinoid (TC) and atypical carcinoid (AC) account for 2% and 0.2% of all lung NETs respectively, and AC tend to be more aggressive. Although both can metastasise, AC are more likely; common sites include bone and liver. Currently, brain imaging is not included in the work-up of TC/AC, as

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Jones J, Spurgeon L, Shaheen F, Lewis A, Mansoor W,

Keywords: typical carcinoid, atypical carcinoid, brain metastases, Ki67,

#3091 A review of outcomes of two sets of 100 consecutive cases of cutaneous basal cell carcinomas of the head and neck managed in an oral and maxillofacial unit at a district general hospital

Introduction: Basal cell carcinomas (BCCs) are often regarded as the ‘mildest’ form of skin cancer, and are the most common type of skin cancer in the United Kingdom [1]. There are various forms of treatment for BCCs. In an Oral and Maxillofacial Surgery (OMFS) unit, the majority of lesions are surgically excised, followed by histopathological examination to determine completeness of excision. This study aimed to analyse the outcome of cases of BCCs excised in our OMFS unit.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Loh M, Archarya S, Parikh S, Jones D,

Keywords: BCC, cancer, surgery,

#1547 Neuroendocrine Tumours of the Thymus: A Report of Four Cases

Introduction: Neuroendocrine tumours of the thymus (thymic carcinoids) are a rare group of malignancies with a reported incidence of about 1 in 5 million. Over a ten year period in our institution, covering a population of 3.5 million, there had only been two confirmed cases.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Richardson C, Henley G, Jones C, Turner R, Anthoney A,

Keywords: -,

#452 Clinical and Psychometric Validation of the Disease-Specific Questionnaire Module (EORTC QLQ-GINET21) in Assessing Quality of Life of Patients with Neuroendocrine Tumors

Introduction: Quality of life (QoL) is an important outcome measure in clinical trials and is increasingly being used as an endpoint. The QLQ-GINET21 is a questionnaire developed with the EORTC QoL Group but which had not previously been validated.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Ramage J, Yadegarfar G, Friend L, Jones L, Plum L,

Keywords: Quality of Life, PROMS,