Urine 5-HIAA levels and quality-of-life in neuroendocrine neoplasia – Is there an association?

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Introduction: Patients with neuroendocrine neoplasia (NEN) experience psychological distress related to secreting tumors. 5-hydroxyindoleacetic acid (5-HIAA) is a metabolite of serotonin, an important secretory product in carcinoid syndrome.

Aim(s): To determine if urine 5-HIAA (u5HIAA) levels correlate with health-related quality of life (HRQL) in patients with NEN.

Materials and methods: A retrospective single-centre cohort study was conducted including 741 patients with histological or radiological diagnosis of NEN. Patients completed standardised questionnaires at clinic appointments. Spot u5HIAA levels were correlated with PHQ-9 (depression), GAD-7 (anxiety), QLQ-GINET21 and EORTC QLQ-C30 scores. Correlation was evaluated with the Spearman rho test.

Conference:

Presenting Author:

Authors: Chaudhry R, White B, Chandrakumaran K, Vincent R, Srirajaskanthan R,

Keywords: neuroendocrine neoplasm, biomarker, 5-HIAA, Health-related quality of life (HRQL),