Abstract Library

#4462 Clustering of gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) using machine learning (ML) and comparison with tumour, node, metastasis (TNM) staging: A population-based study using surveillance, epidemiology, and end results (SEER)

Introduction: TNM 8 is the staging system for GEP-NEN, guiding prognosis and treatment. However, it does not include important prognostic factors such as age, sex, race, and morphology.

Conference:

Presenting Author: Mortagy M

Authors: Mortagy M, El Asmar M, White B, Chandrakumaran K, Ramage J,

Keywords: Clustering, Machine learning, GEP-NEN, TNM Staging, Survival Analysis, SEER,

#4461 Systemic anti-cancer therapy in gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC): Insights from National Cancer Registration and Analysis Service (NCRAS)

Introduction: ENETS advocates the use of platinum-based chemotherapy in combination with Etoposide as first-line chemotherapy in advanced GEP-NEC. Available retrospective evidence is from small studies.

Conference:

Presenting Author: Mortagy M

Authors: Mortagy M, El Asmar M, Paisey S, White B, Chandrakumaran K,

Keywords: Systemic anti-cancer therapy, Chemotherapy, GEP-NEC, NCRAS,

#4384 The efficacy of combination of temozolomide and capecitabine for neuroendocrine tumours: A real-world comparison of outcomes in Alberta, Canada – Patients treated from 2011-2021

Introduction: The combination of capecitabine and temozolomide (CAPTEM) showed PFS benefits in pancreatic neuroendocrine tumours (PNETs).

Conference:

Presenting Author:

Authors: Aleksi A, Malek H, Husi P, Halperin H, White-Gloria C,

Keywords: captem, neuroendocrine tumour, endocrine tumour, progression-free survival, overall survival,

#3732 Urine 5-HIAA levels and quality-of-life in neuroendocrine neoplasia – Is there an association?

Introduction: Patients with neuroendocrine neoplasia (NEN) experience psychological distress related to secreting tumors. 5-hydroxyindoleacetic acid (5-HIAA) is a metabolite of serotonin, an important secretory product in carcinoid syndrome.

Conference:

Presenting Author:

Authors: Chaudhry R, White B, Chandrakumaran K, Vincent R, Srirajaskanthan R,

Keywords: neuroendocrine neoplasm, biomarker, 5-HIAA, Health-related quality of life (HRQL),

#3718 Epidemiology of neuroendocrine neoplasms (NEN) in England 2012-2018 – Home location, incidence and survival including access to neuroendocrine centres of excellence (CoE)

Introduction: Many cancers have been associated with environmental factors but these remain unexplored for NEN. Travel to and from a CoE can be a significant burden to patients. There is evidence that this impacts on treatment outcomes and survival in other cancers.

Conference:

Presenting Author: Nwoguh C

Authors: Nwoguh C, Chandrakumaran K, White B, Russell B, Handford J,

Keywords: neuroendocrine, access to care, neuroendocrine neoplasm, incidence, geospatial, mapping, geographic, survival, environmental factors,