Abstract Library

#4008 Mapping of lymph node metastasis in non-functional pancreatic neuroendocrine tumors: A retrospective analysis of 455 patients

Introduction: Radical surgery is the best and effective option for resectable pancreatic neuroendocrine tumor (pNET) patients. However, lymphadenectomy in pNET surgery remains controversial, especially for small tumors.

Conference:

Presenting Author: Wang F

Authors: Wang F, Jing D, Zhou C, Qin Y, Chen J,

Keywords: Pancreatic neuroendocrine tumor, Lymph node metastasis, Lymph node dissection, Metastasis rate, Lymph node,

#3718 Epidemiology of neuroendocrine neoplasms (NEN) in England 2012-2018 – Home location, incidence and survival including access to neuroendocrine centres of excellence (CoE)

Introduction: Many cancers have been associated with environmental factors but these remain unexplored for NEN. Travel to and from a CoE can be a significant burden to patients. There is evidence that this impacts on treatment outcomes and survival in other cancers.

Conference:

Presenting Author: Nwoguh C

Authors: Nwoguh C, Chandrakumaran K, White B, Russell B, Handford J,

Keywords: neuroendocrine, access to care, neuroendocrine neoplasm, incidence, geospatial, mapping, geographic, survival, environmental factors,

#3647 Autologous ECM-composed scaffolds and zebrafish PDXs for individualized theragnostic in rare neuroendocrine neoplasms

Introduction: Neuroendocrine neoplasms (NENs) are a subgroup of poorly characterized rare tumors with challenging management. Identification of clinically useful biomarkers for treatment tailoring is urgently needed.

Conference:

Presenting Author: Liverani C

Authors: Calabrese C, Miserocchi G, Vanni S, Mercatali L, de Vita A,

Keywords: NGS, zebrafish, autologous scaffold, molecular determinants,

#3462 Development and verification of a new monoclonal OTP specific antibody for pulmonary carcinoid diagnostics

Introduction: Histology-based grading of pulmonary carcinoids (PC) is problematic and subject to high interobserver variation. Orthopedia homeobox (OTP) has shown to be an excellent prognostic marker for PCs, also indicated by the WHO. However, absence of a reliable routinely applicable monoclonal OTP antibody (mAb) hampers implementation in routine diagnostics.

Conference:

Presenting Author: Speel E

Authors: Moonen L, Derks J, Lap L, Marijnissen B, van den Bosch T,

Keywords: Orthopedia Homeobox, pulmonary carcinoid, monoclonal antibody, clinical diagnostics,

#3183 Clinical stratification of pancreatic neuroendocrine tumors by systematically integrating multimodal and clinical data

Introduction: Non-functional pancreatic neuroendocrine tumors (PanNETs) are heterogeneous with at least two transcriptome subtypes with differential biology, immune mechanisms and prognosis. However, it is challenging to understand how multimodal data interact with clinical variables and contribute to the disease heterogeneity and phenotypes.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Sadanandam A

Authors: Sadanandam A, Lawlor R, Mafficini A, Luchini C, Nyamundanda G,

Keywords: pancreatic neuroendocrine tumor, multimodal data integration, multiomics, clinical data integration, machine learning, artificial intelligence, subtypes, pancreatic cancer, phenotypes, PhenMap, mutations, gene expression, microRNA,