Zollinger-Ellison Syndrome: The Esophageal Stricture as a Rare and Severe Complication

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Introduction: Zollinger-Ellison Syndrome (ZES) is caused by tumoral hypersecretion of gastrin, inducing gastric hyperchlorhydria and complicated peptic ulcer disease. Esophageal strictures are rare in ZES, due to early PPI treatment.

Aim(s): To evaluate clinical presentation, treatment, histology and prognosis.

Materials and methods: From 2004 to 2013, we observed three patients with ZES with severe esophageal strictures (out of 20 observed). Endoscopy and barium esophagram performed to detect the esophageal strictures and establish their severity and extension. ZES established by fasting serum gastrin or secretin provocative test, and gastric acid studies. Octreoscan scintigraphy performed for detecting tumor localization.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Liço V, Milanetto A, Moletta L, Vincenzi V, Ruol A,

Keywords: esophageal stricture, ZES, hypergastrinemia,