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#2815 Unexpected High Rate of Metastases in Type 1 Gastric Neuroendocrine Neoplasia
Introduction: Gastric neuroendocrine neoplasms (gNEN) represent about 7.5% of gastroenteropancreatic NEN (gepNEN), classified in: type 1 (70-80%), related to autoimmune gastritis, type 2 (5%), related to Zollinger-Ellison syndrome in multiple endocrine neoplasia 1 and type 3 (15-20%), in absence of hypergastrinemia or mucosal atrophy.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Bottiglieri F, Modica R, de Cicco F, Minotta R, Faggiano A,
Keywords: gastric, neuroendocrine, type1, type3, metastases,
Introduction: Definitions of Type 3 gastric NEN (g-NEN) in ENETS Guidelines 2012 and 2016 are ambiguous and controversial, so Four-type classification has been proposed in China.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Li Y
Authors: Li Y, Zhang P, Qiu X, Li X, Zhang Y,
Keywords: gastric nen, subtype classification,
Introduction: Zollinger-Ellison syndrome (ZES) can cause severe complications. In multiple endocrine neoplasia type 1 (MEN1) related ZES, surgery has a controversial role and proton pump inhibitors (PPI) are usually first-line therapy, although some concerns regarding long-term use. Somatostatin analogs (SSA) both reduce hypergastrinemia and have an antiproliferative role.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Modica R
Authors: Modica R, Pizza G, Lo Calzo F, De Cicco F, Sciammarella C,
Keywords: somatostatin analogs, MEN1, Zollinger-Ellison syndrome,
Introduction: A 58-year-old woman was referred to our hospital for hepatic lesions and thickening of the walls of the stomach detected by abdominal CT scan. An upper GI endoscopy showed a lesion of the body of the stomach and the histopathologic exam documented a well differentiated NET. 68Ga-DOTATOC PET showed pathologic uptake in the stomach and in the liver (3 lesions). Circulating chromogranin A and gastrin were 596 ng/ml and 2283 pg/ml respectively
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Smiroldo V
Authors: Smiroldo V, Carnaghi C, Tresoldi A, Lania A, Bonifacio C,
Keywords: gastric, NET, complete remission, gastrin,