Abstract Library

#356 Activin A in Carcinoid Heart Disease: A Possible Role in Diagnosis and Pathogenesis

Introduction: Carcinoid heart disease (CHD), a complication of NETs, is characterized by right heart fibrotic lesions. In addition to serotonin, cytokines and growth factors with fibrogenic properties may play a role.

Conference:

Presenting Author:

Authors: Bergestuen D, Edvardsen T, Aakhus S, Ueland T, Øie E,

Keywords: Carcinoid heart disease, fibrosis, NETs, activin A,

#47 Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in Patients with Neuroendocrine Tumors

Introduction: Carcinoid heart disease (CHD) is a known complication of neuroendocrine tumors (NETs), particularly of those arising from the small intestine, appendix and proximal colon (previously known as mid-gut carcinoids). CHD is characterized by right heart fibrotic lesions and has traditionally been defined by the degree of valvular involvement, most commonly in the form of tricuspid regurgitation. Right ventricular (RV) dysfunction due to mural involvement may also be a manifestation. Connective tissue growth factor (CCN2) is upregulated in many fibrotic disorders. Increased tumor expression of CCN2 has been shown in patients with small intestinal NETs associated with peritoneal fibrosis. At present, its role in carcinoid heart disease is unknown.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Bergestuen D, Gravning J, Haugaa K, Sahakyan L, Aakhus S,

Keywords: carcinoid heart disease, neuroendocrine tumors, right ventricular function, connective tissue growth factor,