Abstract Library

#1130 Incidence of Neuroendocrine Neoplasms in Norway: A Report of 16 258 Cases from 1993 through 2010

Introduction: Studies show an increasing trend in the incidence of neuroendocrine neoplasms (NENs). A significant number of NENs occur in less common primary sites, but they are often excluded from the population based studies.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Boyar Cetinkaya R

Authors: Boyar Cetinkaya R, Aagnes B, Thiis-Evensen E, Tretli S, Bergestuen D,

Keywords: neuroendocrine, incidence, epidemiology, registry,

#692 Prognostic Factors and Survival in Well-Differentiated Pancreatic Neuroendocrine Tumors

Introduction: Pancreatic neuroendocrine tumors account for 2-3% of all pancreatic neoplasms.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Cetinkaya R

Authors: Boyar Cetinkaya R, Vatn M, Aabakken L, Bergestuen D, Thiis-Evensen E,

Keywords: neuroendocrine, pancreas, prognosis, survival,

#491 International Survey for the Use of Biomarkers and Molecular Imaging in Neuroendocrine Tumors (NET): What we are Using in Daily Practice

Introduction: Several guidelines have given recommendations for optimal use of biomarkers and molecular imaging. However, those guidelines’ implementation may not be always possible due to local policies or lack of access to several diagnostic studies.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Toumpanakis C, Khan M, Bergestuen D, Kim M, Thirlwell C,

Keywords: international survey, biomarker, molecular imaging, NET,

#356 Activin A in Carcinoid Heart Disease: A Possible Role in Diagnosis and Pathogenesis

Introduction: Carcinoid heart disease (CHD), a complication of NETs, is characterized by right heart fibrotic lesions. In addition to serotonin, cytokines and growth factors with fibrogenic properties may play a role.

Conference:

Presenting Author:

Authors: Bergestuen D, Edvardsen T, Aakhus S, Ueland T, Øie E,

Keywords: Carcinoid heart disease, fibrosis, NETs, activin A,

#47 Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in Patients with Neuroendocrine Tumors

Introduction: Carcinoid heart disease (CHD) is a known complication of neuroendocrine tumors (NETs), particularly of those arising from the small intestine, appendix and proximal colon (previously known as mid-gut carcinoids). CHD is characterized by right heart fibrotic lesions and has traditionally been defined by the degree of valvular involvement, most commonly in the form of tricuspid regurgitation. Right ventricular (RV) dysfunction due to mural involvement may also be a manifestation. Connective tissue growth factor (CCN2) is upregulated in many fibrotic disorders. Increased tumor expression of CCN2 has been shown in patients with small intestinal NETs associated with peritoneal fibrosis. At present, its role in carcinoid heart disease is unknown.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Bergestuen D, Gravning J, Haugaa K, Sahakyan L, Aakhus S,

Keywords: carcinoid heart disease, neuroendocrine tumors, right ventricular function, connective tissue growth factor,