Abstract Library

#1723 Evaluation of the Somatostatin and CXCR4 Chemokine Receptor Expression in Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NEN) of Different Origin

Introduction: Somatostatin receptors (SSTR) are known for their overexpression in well-differentiated GEP-NEN, whereas the chemokine receptor CXCR4 is considered to be present mainly in highly proliferative and advanced tumors.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Lupp A

Authors: Mai R, Kaemmerer D, Sänger J, Neubauer E, Schulz S,

Keywords: somatostatin receptor, CXCR4,

#1484 Neuroendocrine Tumors of the Appendix Are Probably Harmless Neoplasms

Introduction: Appendiceal neuroendocrine tumors (aNETs) have a 5-year survival rate between 74% and 95% according to recent data from Cancer Registry of Norway and the United States, respectively. However, in the daily clinical practice one almost never encounters patients suffering from aNETs with distant metastasis or dying of the disease.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Sipos B

Authors: Weysser A, Nieser M, Kloeppel G, Sipos B,

Keywords: NET,

#1302 Differential Somatostatin and CXCR4 Chemokine Receptor Expression in Primary Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NEN) and Their Metastases

Introduction: Somatostatin receptors (SSTR) are known for their overexpression in well-differentiated GEP-NEN, where they serve as molecular targets for different imaging and treatment modalities. The chemokine receptor CXCR4, in contrast, is present mainly in highly proliferative and advanced tumors.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Kaemmerer D, Träger T, Sänger J, Schulz S, Lupp A,

Keywords: somatostatin receptor, chemokine receptor, sstr,

#833 The Chemokine Receptor CXCR4 – Differential Expression in Bronchopulmonary Neuroendocrine Neoplasms

Introduction: The CXCR4 is a plasma membrane chemokine receptor, which is involved in organogenesis, hematopoiesis and inflammation. Additionally, an over-expression is described for many neoplastic tissues. Here, an involvement in tumor progression, metastasis, adaptation to hypoxia and in stem cell survival is postulated.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Reimann C

Authors: Reimann C, Kaemmerer D, Specht E, Wirtz R, Lupp A,

Keywords: neuroendocrine, tumor, SCLC, CXCR4, IHC,

#791 Quantification of Somatostatin Receptor Subtypes Using In Vivo PET/CT-Data, Ex Vivo Conventional Immunohistochemistry and Automated Digitized Analysis by Definiens XD Image Software

Introduction: Diagnostics and therapy of NET are significantly influenced by their somatostatin receptor (SSTR) status. Immunohistochemistry (IHC) of SSTR performed by pathologists is a time-consuming and cost-intensive procedure.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Kaemmerer D, Athelogou M, Lupp A, Schulz S, Peter L,

Keywords: SSTR,