Abstract Library
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ENETS Abstract Search
Introduction: In a two-centre, 12-week, open trial in 16 patients with chronic atrophic gastritis, hypergastrinaemia, multiple gastric NETs, and raised circulating CgA, the gastrin/CCK2 receptor antagonist, netazepide, reduced the tumour number and size, and normalised CgA.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: Boyce M
Authors: Boyce M, Moore A, Parsons B, Lloyd K, Sagatun L,
Keywords: Netazepide,
Introduction: Gastric carcinoids (GC) are tumors arising from enterochromaffin-like (ECL) cells in the gastric mucosa. Most are caused by hypergastrinaemia, which stimulates ECL-cell growth. YF476 is a potent, selective and orally active gastrin receptor antagonist in humans in vitro and in vivo. YF476 prevented and caused shrinkage of GC in animal models of the condition.
Conference: 9th Annual ENETSConcerence (2012)
Presenting Author:
Authors: Boyce M,
Keywords: gastric carcinoids, ECL cells, YF476, OMP,
Introduction: Chronic atrophic gastritis (CAG) results in achlorhydria, hypergastrinemia and, in some patients, gastric carcinoids (type 1 GCs). Type 1 GCs may become malignant and metastasize. Current treatments of type 1 GCs, such as polypectomy, somatostatin analogues and antrectomy, have their disadvantages. YF476 – a potent, selective, orally active and well-tolerated gastrin receptor antagonist in pre-clinical studies – prevented, as well as reduced, the number and size of gastric carcinoids and carcinomas in rodent models.
Conference: 9th Annual ENETSConcerence (2012)
Presenting Author:
Authors: Fossmark R, Sørdal �, Jianu C, Qvigstad G, Boyce M,
Keywords: gastric carcinoids, gastrin, chromogranin A,