#612
Serotonin in Blood: Assessment of its Origin by Concomitant Determination of β-Thromboglobulin (platelets) and Chromogranin A (enterochromaffin cells)
Introduction:
Serotonin is produced in enterochromaffin (EC) cells, taken up and stored in platelets and released during platelet activation. Measurement of platelet-poor plasma serotonin is difficult, mainly due to platelet activation during blood sampling.
Conference:
10th Annual ENETSConcerence (2013)
Presenting Author:
Hauso �
Authors:
Zeinali F,
Fossmark R,
Hauso �,
Wiseth R,
Hjertner �,
Keywords:
β-thromboglobulin,
serotonin,
neuroendocrine tumor,
#406
YF476, a Gastrin Receptor Antagonist, Causes Regression of Tumors and Normalizes Serum Chromogranin A in Patients with Type 1 Gastric Carcinoids
Introduction:
Chronic atrophic gastritis (CAG) results in achlorhydria, hypergastrinemia and, in some patients, gastric carcinoids (type 1 GCs). Type 1 GCs may become malignant and metastasize. Current treatments of type 1 GCs, such as polypectomy, somatostatin analogues and antrectomy, have their disadvantages. YF476 – a potent, selective, orally active and well-tolerated gastrin receptor antagonist in pre-clinical studies – prevented, as well as reduced, the number and size of gastric carcinoids and carcinomas in rodent models.
Conference:
9th Annual ENETSConcerence (2012)
Presenting Author:
Authors:
Fossmark R,
Sørdal �,
Jianu C,
Qvigstad G,
Boyce M,
Keywords:
gastric carcinoids,
gastrin,
chromogranin A,