Abstract Library

#801 Normal Gastrointestinal Neuroendocrine Cells Lack E-cadherin

Introduction: E-cadherin plays a crucial role in the adhesion between epithelial cells and thus epithelial integrity. Moreover, germ line mutations in the E-cadherin gene (CDH1) causing loss of E-cadherin function (adhesion) leads to hereditary gastric cancer of the diffuse type, according to Laurén. Even sporadic gastric carcinomas of the diffuse type often lose E-cadherin expression due to mutations. Lack of E-cadherin has been recorded at an early phase in such carcinomas.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Hauso �

Authors: Hauso �, Nordbø H, Ringnes E, Sørdal �, Nordrum I,

Keywords: E-cadherin, neuroendocrine cell, gastric cancer, adhesion molecules, neuroendocrine tumors, carcinoid,

#612 Serotonin in Blood: Assessment of its Origin by Concomitant Determination of β-Thromboglobulin (platelets) and Chromogranin A (enterochromaffin cells)

Introduction: Serotonin is produced in enterochromaffin (EC) cells, taken up and stored in platelets and released during platelet activation. Measurement of platelet-poor plasma serotonin is difficult, mainly due to platelet activation during blood sampling.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Hauso �

Authors: Zeinali F, Fossmark R, Hauso �, Wiseth R, Hjertner �,

Keywords: β-thromboglobulin, serotonin, neuroendocrine tumor,