Abstract Library

#801 Normal Gastrointestinal Neuroendocrine Cells Lack E-cadherin

Introduction: E-cadherin plays a crucial role in the adhesion between epithelial cells and thus epithelial integrity. Moreover, germ line mutations in the E-cadherin gene (CDH1) causing loss of E-cadherin function (adhesion) leads to hereditary gastric cancer of the diffuse type, according to Laurén. Even sporadic gastric carcinomas of the diffuse type often lose E-cadherin expression due to mutations. Lack of E-cadherin has been recorded at an early phase in such carcinomas.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Hauso �

Authors: Hauso �, Nordbø H, Ringnes E, Sørdal �, Nordrum I,

Keywords: E-cadherin, neuroendocrine cell, gastric cancer, adhesion molecules, neuroendocrine tumors, carcinoid,

#622 Evaluation of Mucin and Neuroendocrine Expression in Diffuse Gastric Cancer with Signet Ring Cell Morphology

Introduction: A proportion of diffuse gastric carcinoma, according to the Lauren classification system, has signet ring cell morphology. Signet ring cells are characterized by a peripherally placed nucleus and a central amorphous substance, which is reported to be mucin based on Periodic Acid Schiff positivity (PAS). PAS is not a specific staining method for mucin. Neuroendocrine expression has previously been reported in tumor cells in diffuse type gastric cancer.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Sørdal �

Authors: Sørdal �, Qvigstad G, Nordrum I, Waldum H,

Keywords: gastric signet ring cell carcinoma, mucin, neuroendocrine markers, PAS,